#Zona fasciculata free

Electrolyte balance in epithelial cells of the submaxillary salivary glands and the large intestine are also under mineralocorticoid control however, the physiologic importance of this phenomenon is likely minimal ( Bastl and Hayslett, 1992).Īldosterone levels are primarily regulated by angiotensin II through the renin-angiotensin-aldosterone system (RAAS) and directly by serum potassium levels.

Therefore aldosterone primarily affects total body volume and not sodium concentration ( Table 106.1) ( White, 1994 Arlt and Stewart, 2005).

#Zona fasciculata free

Although aldosterone levels have a profound effect on total body Na +, concentration of the ion does not change, whereas reabsorption of sodium is accompanied by reuptake of free water. Aldosterone regulates electrolyte metabolism by stimulating epithelial cells of the distal nephron to reabsorb Na + and Cl −, while secreting H + and K +. As a result, the glomerulosa cells of this tissue are the sole source of aldosterone-the primary human mineralocorticoid ( Rainey, 1999). The zona glomerulosa is the outermost region of the adrenal cortex and is the only zone of the adrenal gland that contains the enzyme aldosterone synthase (CYP11B2). Partin MD, PhD, in Campbell-Walsh-Wein Urology, 2021 Zona Glomerulosa